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KMID : 0352519850220030131
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Korea Univercity Medical Journal
1985 Volume.22 No. 3 p.131 ~ p.138
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The effects of capsaicin on the mechanoreceptor of the cat´s paw
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Abstract
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The present study was performed to investigate the effect of capsaicin on the pressure receptors and its innervating nerve fibers after applying the capsaicin to the skin or subcutis of the cat´s paw. The results are summarized as follows:
1. Application of 0.05m1 capsaicin (15gm%) to the skin induced to increase the threshold and decrease the conduction velocity of A-beta nerve fiber from pressure receptor. Injection of 0.05m1 capsaicin(1.5gmo) into the subcutis induced to more increase the threshold and more decrease the conduction velocity of A-beta nerve fiber from pressure receptor than application to the skin.
2. Injection of 0.05ml capsaicin(1.5gm%) to the subcutis induced to more increase the threshold and more decrease the conduction velocity of A-delta nerve fiber from pressure receptor than A-beta nerve fiber.
3. After the application of 0.05m1 capsaicin(15gmo) to the skin, the impulse discharges of A-beta nerve fiber to pressure stimuli increased initially by 8.319.2% to the peak discharge and later decreased by 13.2^24. Vol. And in case of injection of 0.05ml capsaicin (1. 5 gm%) into the subcutis, it increased initially by 18.427.8% but decreased gradually and disappeared completely.
4. After the injection Of 0.05ml capsaicin (1.5gra%) into the subcutis, the impulse discharges of A-delta nerve fiber to pressure stimuli increased initially by 33.254.8% but decreased gradually and completely disappeared after a shorter time than A-beta.
According to above results, capsaicin seemed to depress the activity not only of nociceptors but also of simple pressure receptors. And it suggested that the general concept which explains that capsaicin would desensitize or degenerate the nociceptors or pain conducting fibers selectively should be reconsidered.
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